Unveiling the DNA Effect of Strong Cannabis Strains
Scientists at King’s College London have unveiled groundbreaking evidence that consistent use of strong cannabis strains could imprint unique molecular signatures onto a person’s DNA. These signatures have the potential to influence genes tasked with managing the body’s energy resources and its immune system operations.
Influence on Genetic Vulnerability
The revelation suggests that individuals who frequently consume potent cannabis may have an innate genetic vulnerability to developing psychotic disorders. Published in the journal Molecular Psychiatry, the study highlighted discernible alterations in DNA methylation patterns amongst habitual cannabis users with a history of psychosis compared to those without such episodes.
Potential for DNA Blood Tests
Significantly, these findings raise the prospect of developing DNA blood tests to determine heightened risks of psychosis associated with cannabis consumption. Dr. Emma Dempster, the leading author of the study, stated, “This study is the first of its kind to illustrate that habitual use of strong cannabis can lead to precise molecular changes in DNA, particularly influencing genes associated with energy and immune operations.”
Dr. Dempster further noted that the study sheds light on the ways in which cannabis use can alter fundamental biological functions.
Investigation and Findings
The investigation involved a sophisticated scrutiny of DNA methylation throughout the human genome, utilizing blood samples from subjects undergoing their initial psychosis incidents and those with no history of such conditions. It included a group of 239 individuals having their first psychosis episode and 443 unaffected individuals from countries such as England, France, the Netherlands, Italy, Spain, and Brazil.
The study, which received funding from the Medical Research Council, the National Institute for Health and Care Research (NIHR) Maudsley Biomedical Research Centre (BRC), and the NIHR Exeter BRC, underscores the capability of cannabis to impact DNA, apart from the known consequences of tobacco, which is frequently combined with cannabis in smoking preparations.
Significance of the Study
Professor Marta Di Forti, a leading contributor to the study and an expert in the interplay between drugs, genetics, and psychotic disorders, highlighted the significance of these findings. She pointed out the necessity of understanding the physical effects of cannabis, particularly as its use and the accessibility of strong variants continue to rise.
Advancing Research to Detect Increased Psychosis Risk
King’s College London’s Franca Davenport, in charge of media relations, reiterated the institution’s dedication to advancing research efforts. The aim is to investigate whether the DNA signatures left by cannabis consumption could assist in detecting those with an increased psychosis risk. Information from this study contributes meaningfully to the ongoing discourse surrounding the physiological consequences of cannabis use, potentially sparking the development of genetic-based preventative approaches in the realm of mental health.
